Problem and Countermeasure on Development of Pharmaceuticals from Actinomycete Resources

Abstract:

Development of antibiotics from actinomycetes has acquired enormous accomplishment. About 12000 bioactive metabolites were discovered from actinomycetes. Up to now it is very difficult to finding novel compounds with bioactivities from microorganisms. Advance of discovery of new actinomycete species from extreme environments and ocean, integration of modern chemical techniques and database, and genomic techniques are reviewed for meeting the challenge and difficulty in pharmaceutical development from actinomycetes in this paper.