Development trends of phage synthetic biology based on patent intelligence

Abstract:

[Background] As a new interdisciplinary subject, synthetic biology has shown great application potential in many fields such as medicine, agriculture, and industry. Bacteriophages, recognized as a pivotal research focus in synthetic biology, exhibit considerable potential for diverse applications. [Objective] The study aims to reveal the global development trends and technological advancements in phage synthetic biology through patent analysis, and to clarify its potential and challenges in future applications. [Methods] The patent analysis was carried out in multiple dimensions including patent application trend, technology structure, technology source country, legal status, and comparison between China and the United States, to comprehensively evaluate the global patent distribution and development dynamics of phage synthetic biology. [Results] The study finds that relevant technological advancements are primarily concentrated in areas such as phage genome modification, phage therapy, and phage display. However, patent data reveal imbalances in the current research regarding technological distribution and application directions, with notable gaps in biosafety and ethical considerations. [Conclusion] According to the results, we put forward the following suggestions: developing a forward-looking patent layout, strengthening global layout and protection of patents in key domains, and highlighting biosafety and application ethics.

Key words:phage;synthetic biology;patent analysis;technological progress;trend analysis