Epidemic situation of zoonotic bacterial diseases and strategies for combating antibiotic-resistant bacteria

Abstract:

Zoonotic diseases, caused by the same pathogen and naturally transmitted between humans and vertebrate animals, have become a major global issue that urgently needs to be addressed. Currently, zoonotic diseases account for 60% of globally emerging and existing infectious diseases. The zoonotic diseases caused by Brucella, Mycobacterium bovis, Bacillus anthracis, Streptococcus suis serotype 2, Salmonella, and Klebsiella pneumoniae pose serious threats to the healthy development of animal husbandry, public health, and national biosafety. The situation for prevention and management of these diseases is getting increasingly severe. This article reviews the current prevalence of zoonotic bacterial diseases caused by the six pathogens mentioned above, as well as their antibiotic resistance mechanisms and novel antibacterial strategies, serving as a reference for the prevention and control of these diseases.

Key words:zoonotic bacteria;epidemiological characteristics;mechanism of antibiotic resistance;therapeutic strategies