“Battle” between Brucella infection and programmed cell death of the host cell

Abstract:

Brucellosis caused by Brucella infection is a major bacterial zoonosis, presenting a global prevalence situation. Brucellosis poses severe threats to the health of human and livestock, imposing substantial socio-economic burdens in certain regions. The invasion and establishment of chronic or even lifelong infection by Brucella in the hosts largely reply on its sophisticated immune evasion strategies and complex intracellular replication mechanisms. The manipulation of programmed cell death, such as apoptosis, pyroptosis, and autophagy, is a key strategy for the immune evasion of Brucella. Therefore, in-depth research on the ways Brucella regulates programmed cell death in host cells and their significance can provide valuable references for understanding the infection mechanism of Brucella and identifying potential drug targets. This paper summarizes the recent progress in the precise regulatory mechanisms and the “battle” between Brucella infection and various forms of programmed cell death in hosts.

Key words:Brucella;immune evasion;programmed cell death;apoptosis;pyroptosis;autophagy