Research Progress on the Microbial Urate Oxidase

Abstract:

Urate oxidase belonging to the purine degradation pathway, catalyzes the oxidation of uric acid to allantoin. It′s useful for enzymatic determination of urate in clinical analysis. It can also be used as protein drug for treatment of gout, hyperuricemia and tumor lysis syndrome (TLS). The source, enzyme property, genetic engineering and application of uricase were reviewed in this paper.