Advance in Study on the Role of Toll-like Receptors During the Invasion of Aspergillus fumigatus into Host Cell

Abstract:

During invasion of Aspergillus fumigatus into host cells，there is an obvious cellular actin cytoskeleton rearrangement. Toll-like receptors (TLRs)，one of the most important PRRs （pattern recognizing receptors）, can tigger the intracellular signaling transduction to induce the innate immunity, meanwhile be involved in regulating bacteria-associated cellular actin cytoskeleton rearrangement. The PAMPs(pathogen-assosiated molecular patterns) of Aspergillus fumigatus can be recognized by TLR2 and TLR4, nevertheless, the role of TLRs in the regulation of cellular actin cytoskeleton rearrangement during invasion remains unclear. Further studies on the internalization of Aspergillus fumigatus through TLRs will contribute significantly to our understanding of regulation on invasion of Aspergillus fumigatus, eventually provide some ways to cure the fungal infection.