Molecular Resistance Mechanisms of Candida albicans to Antifungal Agents

Abstract:

In recent years，with the increasing of immunocompromised patients in clinical practice，invasive candidiasis has been increased accordingly. Although several antifungal drugs，including polyenes，azoles，5-flucytosine，and echinocandins，have been used widely to treat invasive candidiasis，the treatment failure that caused by the resistance of Candida albicans to these antifungal drugs have been reported widely. Here，we reviewed the molecular mechanisms of resistance to azoles，polyenes，5-flucytosine，and echinocandins，such that to provide an update on these issues.