Recent advances in the flagellar type III secretion system and effectors of Campylobacter jejuni

doi:10.13344/j.microbiol.china.240530

Home > Archive>Volume 52, Issue 2, 2025 >501-509. DOI:10.13344/j.microbiol.china.240530

Recent advances in the flagellar type III secretion system and effectors of Campylobacter jejuni
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                        10.13344/j.microbiol.china.240530
                    
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                        WU JinliangWU Jinliang
Beijing Key Laboratory for Prevention and Control of Infectious Diseases in Livestock and Poultry, Institute of Animal Husbandry and Veterinary Medicine, Beijing Academy of Agriculture and Forestry Sciences, Beijing 100097, China;Animal Science and Technology College, Beijing University of Agriculture, Beijing 102206, China
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CUI YifangCUI Yifang
Beijing Key Laboratory for Prevention and Control of Infectious Diseases in Livestock and Poultry, Institute of Animal Husbandry and Veterinary Medicine, Beijing Academy of Agriculture and Forestry Sciences, Beijing 100097, China
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GUO FangfangGUO Fangfang
Beijing Key Laboratory for Prevention and Control of Infectious Diseases in Livestock and Poultry, Institute of Animal Husbandry and Veterinary Medicine, Beijing Academy of Agriculture and Forestry Sciences, Beijing 100097, China
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HU GeHU Ge
Animal Science and Technology College, Beijing University of Agriculture, Beijing 102206, China
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XU FuzhouXU Fuzhou
Beijing Key Laboratory for Prevention and Control of Infectious Diseases in Livestock and Poultry, Institute of Animal Husbandry and Veterinary Medicine, Beijing Academy of Agriculture and Forestry Sciences, Beijing 100097, China
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Abstract:

Campylobacter jejuni is one of the most common foodborne pathogenic bacteria worldwide. Humans and animals infected by C. jejuni exhibit different clinical symptoms and pathological changes. Domesticated birds infected by this pathogen did not present clinical symptoms, becoming the main source of human infection. Elucidating the mechanisms of infection and colonization plays a key role in the prevention and control of C. jejuni. C. jejuni secretes effectors through the flagellar type III secretion system (T3SS). The effectors are injected into host cells and bind to intracellular proteins, thus regulating the signaling pathways and altering the defense mechanisms of host cells. Therefore, the effectors play an important role in the infection and colonization of C. jejuni. This article reviews the flagellar T3SS of C. jejuni, the types and mechanisms of T3SS effectors, and the roles of T3SS effectors in infection and colonization of C. jejuni. This review is of great significance for a deeper understanding of the disease-inducing mechanism of C. jejuni.

Key words:Campylobacter jejuni;flagellar type III secretion system;bacterial effector;Campylobacter invasion-related antigen

Reference

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WU Jinliang, CUI Yifang, GUO Fangfang, HU Ge, XU Fuzhou. Recent advances in the flagellar type III secretion system and effectors of Campylobacter jejuni[J]. Microbiology China, 2025, 52(2): 501-509

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Received:June 30,2024
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Adopted:August 01,2024
Online: February 22,2025
Published: February 20,2025

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