Abstract:Medical Microbiology is a core compulsory course for medical students. Under the background of developing New Medicine, which emphasizes disciplinary crossing, system integration, and advanced technology, we have taken measures to reform and innovate the teaching of Medical Microbiology in view of the weakness in application ability, overall view and critical thinking, and prevention and responsibility senses. Specifically, we designed the curriculum objectives based on explicit and implicit subjects, reorganized the teaching contents aimed at cultivating systematic thinking and critical thinking, and built a teaching model characterized by four combinations (lecturing and discussion, professional knowledge and practical cases, basic knowledge and frontiers, and online blended with offline) and a developmental multiple evaluation system. The innovation results show that students’ academic performance, knowledge application ability, systematic thinking, critical thinking, professional responsibility sense, and innovation drive have been significantly improved. This study provides a new direction for the teaching reform of basic curriculums from the view of New Medicine.