Abstract:As the first class of Medical Microbiology, the “Introduction” plays a crucial role in guiding the course. Our team carried out the “student-centered” teaching design based on the results of the pre-class questionnaires and adopted the blended teaching mode of three stages-two combinations (before class, during class, and after class; online-offline). The key knowledge points of this class were linked through “3W (Who, What, Why)+1H (How)”, and the knowledge system of Medical Microbiology that was led by the “Introduction” was constructed. A multiple evaluation system combining process evaluation and terminal evaluation was established. The results showed that the improved teaching design helped students gain a deeper understanding of the importance of this course and aroused their interest in learning. Moreover, it helped them understand the course features, master the overall knowledge framework, set up learning goals, and develop effective learning schemes, thereby improving the teaching quality. Additionally, we integrated ideological and political education into the teaching process to foster students’ patriotic sentiments, scientific literacy, and professional accomplishment, thus cultivating medical talents with both virtue and ability.