全球微生物群系研究态势分析

Global research landscape of microbiome

摘要:

【背景】 从“微生物组”到“微生物群系”的更名预示着microbiome研究观念和手段的重大变化。【目的】 了解全球微生物群系领域发展现状和差异，为中国更好地促进微生物群系研究和发展提供对策建议支撑。【方法】 结合政策调研、文献计量与专利分析结果，对全球微生物群系领域在战略环境、基础研究、专利布局、临床转化4个方面的差异进行比较分析。【结果】 全球微生物群系战略布局以美洲的美国、加拿大及欧盟为先导，基础研究逐步深入，专利技术进入快速发展期，但成果临床转化率不足；我国微生物群系领域研究虽然起步较晚，但近年来我国在基础研究与专利研发上展现出了更强的增长劲头。【结论】 为加快我国微生物群系与大健康发展，提出健全与健康产业发展相适应的监管体系、强化微生物群系企业创新主体地位及加强微生物群系与大健康领域人才梯队建设3条相应建议。

关键词:微生物群系;战略布局;专利分析

Abstract:

[Background] The renaming of “microbiome” signifies changes in the conceptual understanding and research methodologies of microbiomes. [Objective] To understand the development status and differences in the field of microbiomes around the world and provide countermeasures and suggestions for China to promote the research and development of microbiomes. [Methods] On the basis of the results from policy research, bibliometrics, and patent analysis, this paper compares the status of the microbiome field around the globe from four aspects: strategic environment, basic research, patent layout, and clinical translation. [Results] The global strategic layout of microbiomes was led by the United States, Canada, and the European Union. The basic research in this field has gradually deepened, and the patented technology has entered a stage of rapid development. However, the clinical translation of research results was insufficient. China started late in the research on microbiomes but demonstrated rapidly increasing basic studies and patents. [Conclusion] In light of these results, three suggestions are proposed to accelerate the development of microbiome research and application in improving one health in China. The three suggestions are establishing a regulatory system aligned with development of the healthy industry, strengthening the role of microbiome enterprises as innovation leaders, and fostering talent pipelines in the microbiome and one health fields.

Key words:microbiome;strategic layout;patent analysis