金黄色葡萄球菌致膜损伤毒素及拮抗的天然药物研究进展

Research progress in membrane-damaging toxins of Staphylococcus aureus and natural anti-toxin medicines

摘要:

金黄色葡萄球菌(Staphylococcus aureus)在感染过程中分泌多种毒素，对宿主细胞膜损伤的毒素是其中一类较为关键的毒素。天然药物具有结构多样性、毒性低等特点，因此，从植物、动物、微生物中寻找药物先导化合物具有极好的潜力。本文针对引起细胞膜损伤毒素的性质、结构特点、作用方式进行综述，对部分抗致膜损伤毒素的天然药物进行总结，为今后新型药物的选择和对抗毒素的治疗手段提供依据。

Abstract:

Staphylococcus aureus secretes a variety of toxins in the course of infection, and the toxins damaging the host cell membrane have garnered great attention. Natural medicines are characterized by structural diversity and low toxicity, and thus it has great potential to mine lead compounds from plants, animals, and microorganisms. This paper reviews the properties, structural characteristics, and mechanism of membrane-damaging toxins and summarizes the natural medicines against these toxins, providing a basis for the selection of new drugs and the development of anti-toxin therapies in the future.