基于文献计量学的炎症性肠病粪菌移植领域研究热点与趋势分析

Bibliometric analysis of research hotspots and trends in fecal microbiota transplantation for inflammatory bowel disease

摘要:

【背景】 目前，临床上尚无根治炎症性肠病的有效方法。越来越多的研究者将粪菌移植应用于炎症性肠病的治疗，以期探究出更安全有效的辅助治疗方法。【目的】 对比分析国内外炎症性肠病粪菌移植领域中的研究热点及前沿趋势，以期为临床医护人员提供新思路和研究方向。【方法】 采用CiteSpace 6.2.R6软件对中国知网(China National Knowledge Infrastructure, CNKI)和Web of Science (WOS)核心合集2003年1月至2024年1月期间收录的炎症性肠病粪菌移植领域的文献进行可视化分析。【结果】 共纳入882篇文献，其中包括664篇英文文献和218篇中文文献。国外炎症性肠病粪菌移植领域的研究热点与趋势主要聚焦于粪菌移植前后的肠道微生物群变化与临床结局之间的关系、安全性问题及作用机制；国内主要聚焦于粪菌移植联合治疗方案、安全性及作用机制。【结论】 国内外研究者对粪菌移植治疗炎症性肠病研究的关注度逐年增加，但仍存在一定的差距。国内机构间的合作有待进一步加强，以共同致力我国炎症性肠病患者粪菌移植领域的发展，同时应充分发挥护士在该领域的作用以构建完善的医疗护理体系。

Abstract:

[Background] Since no effective method is available in clinical practice to cure inflammatory bowel disease (IBD), an increasing number of researchers are applying fecal microbiota transplantation (FMT) to the treatment of IBD, hoping to develop safe and effective supplementary therapies. [Objective] To present innovative research concepts and avenues for clinical medical practitioners by reviewing the research hotspots and frontiers concerning FMT for IBD. [Methods] We employed CiteSpace 6.2.R6 to visually analyze the publications about FMT for IBD. The data were gathered from the China National Knowledge Infrastructure and Web of Science, spanning the period from January 2003 to January 2024. [Results] A total of 882 publications were included in this study, encompassing 664 publications in the English language and 218 in Chinese. The results unveiled that the publications in the English language principally focused on the interplay between post-FMT alterations in gut microbiota and resultant clinical outcomes, safety evaluation, and mechanisms of action. The publications in Chinese centered predominantly on the therapeutic protocols involving FMT, safety evaluation, and mechanisms of action. [Conclusion] Both domestic and overseas researchers have augmented their attention toward FMT for IBD. Nonetheless, discernible disparities persist between China and other countries in this realm. There exists a vital need for enhanced collaboration among domestic institutions, which can foster collective impetus to propel the advances in FMT for IBD patients in China. In addition, the pivotal engagement of nurses is imperative for the establishment of a robust medical care framework within this sphere.