肺炎克雷伯菌外膜囊泡研究进展

Progress in outer membrane vesicles derived from Klebsiella pneumoniae

摘要:

肺炎克雷伯菌(Klebsiella pneumoniae, KP)是临床上常见的条件致病菌，其发病机制涉及复杂的病原体-宿主相互作用网络。尽管我们对这种细菌的分子和细胞机制有了深入的了解，但关于肺炎克雷伯菌外膜囊泡(outer membrane vesicles, OMVs)及其在细菌发病机制中的作用仍未得到充分的阐明。我们总结了目前有关肺炎克雷伯菌外膜囊泡组成成分的知识，重点阐述了其在肺炎克雷伯菌存活和致病等方面的生物学功能。

Abstract:

Klebsiella pneumoniae is a prevalent clinical conditional pathogen. K. pneumoniae infection involves a complicated network of pathogen-host interactions. Despite the profound knowledge about the molecular and cellular mechanisms of this bacterium, studies remain to be carried out regarding the outer membrane vesicles (OMVs) derived from K. pneumoniae and their role in bacterial pathogenesis. We summarized the current knowledge on the components of OMVs derived from K. pneumoniae and reviewed the research progress in the roles of OMVs in the survival and pathogenicity of K. pneumoniae.