转录调控因子BldD调控链霉菌形态分化和次级代谢的研究进展

Progress in the regulation of morphological differentiation and secondary metabolism of Streptomyces by the transcriptional regulator BldD

摘要:

链霉菌(Streptomyces sp.)是一种具有复杂形态分化和生命周期的革兰氏阳性土壤细菌，同时具有强大的次级代谢能力。链霉菌的次级代谢产物种类丰富，其中最重要的就是抗生素类药物。在链霉菌形态分化和次级代谢过程中常常伴随着复杂的调控机制，包括特异性调控、多效性调控和全局性调控等。“bld”是一类链霉菌正常发育所必需的调节基因，因其缺失后能够引起菌株出现“光秃” (bald)的表型而得名。在“bld”类基因编码的诸多转录因子中，BldD作为全局性调控因子，能够显著地调控链霉菌的形态分化和次级代谢。本文主要综述了转录调控因子BldD的结构特征，以及代表性的链霉菌中BldD调控菌株形态分化和次级代谢的分子机制，为深入探讨BldD调控模式的普适性和特异性提供参考。

Abstract:

Streptomyces is a genus of Gram-positive soil bacteria with complex morphological differentiation and life cycle. It has strong secondary metabolic capacity and can produces a variety of antibiotics. The growth of Streptomyces is often associated with morphological differentiation and secondary metabolism, which involve complex regulatory mechanisms, including pathway-specific regulation, pleiotropic regulation, and global regulation. The bld gene family is essential for the normal morphological development of Streptomyces and named since its deletion causes the “blad” phenotype. BldD, a global regulator encoded by a member of the bld family, can significantly regulate the morphological differentiation and secondary metabolism of Streptomyces. This review introduces the structure of BldD and the effects of BldD on the morphological differentiation and secondary metabolism of representative strains of Streptomyces, providing a reference for revealing the molecular regulatory mechanism of BldD in Streptomyces.