肠道菌群与肝细胞癌相关研究的文献计量学分析

Bibliometric analysis of studies relating gut microbiota to hepatocellular carcinoma

摘要:

【背景】肠道菌群与肝细胞癌的关系密切，对肝脏代谢和免疫产生影响。肠道菌群与肝细胞癌的相关研究引起了持续关注。【目的】分析2003–2023年近20年国内外在肠道菌群与肝细胞癌研究领域的发展趋势、研究现状和热点，为该领域的研究者提供更全面、直观的参考。【方法】分别检索Web of Science Core Collection (WoSCC)数据库和中国知网(China national knowledge infrastructure, CNKI)数据库中肠道菌群与肝细胞癌研究领域的相关文献，利用VOSviewer1.6.19、CiteSpace6.1.R6进行文献计量分析。【结果】分别从WoSCC数据库中检索出符合条件的英文文章659篇，CNKI数据库中检索出符合条件的中文文献70篇，英文文献数量和被引次数逐年增加，中文发文数量总体也呈上升的趋势。中国在发文数量和国际合作方面领先，而美国在被引次数和国际合作方面占优。最有影响力的研究机构为University of California San Diego，最有影响力的学者/团队是Elinav Eran团队，发文最多的期刊为International Journal of Molecular Sciences。关键词共现分析发现，肝细胞癌的发病机制、肠道菌群与非酒精性脂肪性肝病发生发展的关系和以肠道菌群为靶点的肝细胞癌治疗方案是该领域的研究热点，关键词突现显示“gut microbiome”和“immune checkpoint inhibitor”是当前该领域的研究前沿。【结论】本研究从文献计量学角度深入分析了肠道菌群与肝细胞癌关系的研究现状和发展趋势，为研究者在该领域深入挖掘热点和前沿、选择合适的期刊和合作伙伴提供指导。

Abstract:

[Background] Gut microbiota is closely associated with hepatocellular carcinoma, impacting liver metabolism and immune responses. Ongoing attention is drawn to the study of gut microbiota-related mechanisms and treatment strategies. [Objective] Analyzing the trends, current status, and hotspots in domestic and international research on gut microbiota and hepatocellular carcinoma from 2003 to 2023, aiming to provide comprehensive and intuitive references for researchers in this field. [Methods] The articles about gut microbiota and hepatocellular carcinoma were retrieved from the Web of Science Core Collection (WoSCC) and China National Knowledge Infrastructure (CNKI). VOSviewer1.6.19 and CiteSpace6.1.R6 were used for bibliometric analysis. [Results] A total of 659 eligible English publications were retrieved from the WoSCC, and 70 Chinese publications meeting the criteria were screened out from the CNKI. The annual count and citation frequency of English publications showed an increasing trend, and the total number of Chinese publications also exhibited a rising trend. China was a leading country in terms of the publication number and international collaborations, while the United States exceled in citation frequency and international partnerships. The most influential research institution was the University of California San Diego, and the most impactful scholar/team identified was the Elinav Eran team. The International Journal of Molecular Sciences was the journal with the largest publication number. The co-occurrence analysis of keywords revealed that the research hotspots included the mechanisms of hepatocellular carcinoma occurrence, the relationship between gut microbiota and non-alcoholic fatty liver disease progression, and hepatocellular carcinoma treatment strategies targeting gut microbiota. The keyword burst analysis highlighted gut microbiome and immune checkpoint inhibitor as the current research frontiers in this field. [Conclusion] This study, from the perspective of bibliometrics, comprehensively analyzed the current status and development trends of the relationship between gut microbiota and hepatocellular carcinoma, and offered guidance for researchers in this field to delve into hotspots and frontiers and to choose suitable journals and collaborators.