人布鲁氏菌病致病机制及治疗研究进展

Research progress in the pathogenesis and treatment of human brucellosis

摘要:

人布鲁氏菌病(布病)是由兼性细胞内病原体布鲁氏菌(Brucella)引起的一种人畜共患病。人常通过直接接触受感染的动物或食用动物产品而获得感染。布鲁氏菌病因其临床表现不特异，治疗不及时易转为慢性，严重影响患者的生存质量。因此，了解病原体致病特点、与宿主细胞的相互作用机制和治疗现状可为临床诊疗提供新方向。本文阐述了布鲁氏菌感染机制、宿主(人)先天性及适应性反应机制，以及目前布鲁氏菌病临床特点和治疗方略，为人布鲁氏菌防治提供参考。

Abstract:

Human brucellosis is a zoonotic disease caused by the facultative intracellular pathogen Brucella. Humans often become infected through direct contact with infected animals or by eating animal products. Because of the unspecific clinical manifestations, brucellosis is easy to become chronic without timely diagnosis and treatment, which seriously affects the quality of life of the patients. Therefore, understanding the pathogenic characteristics of the pathogen, the mechanism of host-pathogen interaction, and the current treatment status can provide a new direction for the clinical diagnosis and treatment of brucellosis. This paper describes the infection mechanism of Brucella, the innate and adaptive response mechanisms of the host (human), and the current clinical characteristics and treatment strategies of brucellosis, aiming to provide reference for the prevention and treatment of human brucellosis.