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微生物学通报

2025年5月8日 周四
首页 > 过刊浏览>2024年第51卷第7期 >2326-2336. DOI:10.13344/j.microbiol.china.230482
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临床肺炎克雷伯菌的异质性耐药研究进展
作者:
  • 史梦兰

    史梦兰

    广东省科学院微生物研究所 华南应用微生物国家重点实验室 农业农村部农业微生物组学与精准应用重点实验室 农业农村部农业微生物组学重点实验室 广东省菌种保藏与应用重点实验室, 广东 广州 510070;浙江海洋大学国家海洋设施养殖工程技术研究中心, 浙江 舟山 316022
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  • 李文茹

    李文茹

    广东省科学院微生物研究所 华南应用微生物国家重点实验室 农业农村部农业微生物组学与精准应用重点实验室 农业农村部农业微生物组学重点实验室 广东省菌种保藏与应用重点实验室, 广东 广州 510070
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  • 谢小保

    谢小保

    广东省科学院微生物研究所 华南应用微生物国家重点实验室 农业农村部农业微生物组学与精准应用重点实验室 农业农村部农业微生物组学重点实验室 广东省菌种保藏与应用重点实验室, 广东 广州 510070
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基金项目:

广东省基础与应用基础研究项目(2021A1515011080)


Research progress in heteroresistance of Klebsiella pneumoniae to antibiotics
Author:
  • SHI Menglan

    SHI Menglan

    Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Key Laboratory of Agricultural Microbiome, Ministry of Agriculture and Rural Affairs, Key Laboratory of Agricultural Microbiomics and Precision Application, Ministry of Agriculture and Rural Affairs, State Key Laboratory of Applied Microbiology Southern China, Institute of Microbiology, Guangdong Academy of Sciences, Guangzhou 510070, Guangdong, China;National Engineering Research Center for Marine Aquaculture, Zhejiang Ocean University, Zhoushan 316022, Zhejiang, China
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  • LI Wenru

    LI Wenru

    Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Key Laboratory of Agricultural Microbiome, Ministry of Agriculture and Rural Affairs, Key Laboratory of Agricultural Microbiomics and Precision Application, Ministry of Agriculture and Rural Affairs, State Key Laboratory of Applied Microbiology Southern China, Institute of Microbiology, Guangdong Academy of Sciences, Guangzhou 510070, Guangdong, China
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  • XIE Xiaobao

    XIE Xiaobao

    Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Key Laboratory of Agricultural Microbiome, Ministry of Agriculture and Rural Affairs, Key Laboratory of Agricultural Microbiomics and Precision Application, Ministry of Agriculture and Rural Affairs, State Key Laboratory of Applied Microbiology Southern China, Institute of Microbiology, Guangdong Academy of Sciences, Guangzhou 510070, Guangdong, China
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  • 摘要
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  • 参考文献 [65]
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    摘要:

    肺炎克雷伯菌(Klebsiella pneumoniae)是临床引起感染的常见病原菌之一，常引发肺炎、尿路感染和细菌血症等。近年来，肺炎克雷伯菌的异质性耐药相关研究相继被报道。异质性耐药是指同一菌株中同时存在对某种抗生素耐药和敏感亚群的现象，由于其表型和遗传不稳定，至今尚无标准、低成本和高效的检测方法。本文对肺炎克雷伯菌异质性耐药进行综述，阐明了异质性耐药的定义和检测方法，并结合本团队在铜绿假单胞菌(Pseudomonas aeruginosa)异质性耐药方面的研究工作，深入剖析了肺炎克雷伯菌的异质性耐药机制。本文为全面了解肺炎克雷伯菌异质性耐药机制、优化临床抗菌药物的使用和治疗肺炎克雷伯菌感染提供参考。

    Abstract:

    Klebsiella pneumoniae (KP), one of the most common pathogens causing clinical infections, often results in pneumonia, urinary tract infection, and bacteremia. In recent years, studies have reported the heteroresistance of K. pneumoniae. Heteroresistance refers to the phenomenon that there are both resistant and susceptible subpopulations of a strain to an antibiotic. Due to the phenotypic and genetic instability of heteroresistance, standard, low-cost, and efficient detection methods remain to be established. This article reviews the research progress in heteroresistance of K. pneumoniae, clarifies the definition and detection methods of heteroresistance, and probes into the heteroresistance mechanism of K. pneumoniae on the basis of our previous studies about the heteroresistance of Pseudomonas aeruginosa. This article will provide a reference for comprehensively understanding the heteroresistance mechanism of K. pneumoniae, optimizing the clinical use of antibiotics, and treating bacterial infections.

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史梦兰,李文茹,谢小保. 临床肺炎克雷伯菌的异质性耐药研究进展[J]. 微生物学通报, 2024, 51(7): 2326-2336

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  • 收稿日期:2023-06-16
  • 录用日期:2023-10-23
  • 在线发布日期: 2024-07-20
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