衣原体与线粒体相互作用机制研究进展

Research progress in the mechanisms of interactions between Chlamydia and mitochondria

摘要:

衣原体是介于病毒和细菌之间的一类原核型微生物，严格在真核细胞内寄生，具有独特的发育周期。基于胞内生长的特性，衣原体能与宿主细胞内多种细胞器发生相互作用以促进自身生存和繁殖。线粒体是细胞内的多功能细胞器，不仅是细胞的代谢中枢和能量工厂，还涉及调控多种生物学过程，在抗菌防御过程中发挥着重要作用。衣原体感染与线粒体存在紧密联系，研究表明衣原体严格依赖宿主细胞线粒体代谢获取能量，并通过改变线粒体蛋白质组成影响线粒体功能，参与调控线粒体动力学、凋亡、活性氧等多种途径。本文就衣原体与宿主细胞线粒体之间的相互作用机制进行综述。

Abstract:

Chlamydia is a genus of prokaryotic microorganisms that lies between viruses and bacteria, strictly parasitizing eukaryotic cells and possessing a unique developmental cycle. Based on the characteristics of intracellular growth, Chlamydia can interact with multiple organelles in host cells to promote its own growth and replication. Mitochondria, multifunctional organelles in cells, not only serve as the metabolic center and energy factory but also are involved in various biological processes, playing an important role in the defense against pathogen invasion. Chlamydia infection is closely related to mitochondria. Studies have shown that Chlamydia relies on the mitochondrial metabolism of host cells to obtain energy and affects mitochondrial functions by changing mitochondrial protein composition and regulating mitochondrial dynamics, apoptosis, reactive oxygen species, etc. This article reviews the interaction mechanisms between Chlamydia and mitochondria in host cells.