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细菌对过氧化氢应激反应研究现状的可视化分析与发展趋势展望
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国家自然科学基金(31800027);湖北省教育厅科学技术研究计划重点项目(D20211004);区域开发与环境响应湖北省重点实验室开放基金[2019(A)002];农业微生物国家重点实验室开放基金(AMLKF202004)


Visualization of research status and prediction of development trends in bacterial responses to hydrogen peroxide stress
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    摘要:

    【背景】过氧化氢(H2O2)作为一种环境友好型的消毒剂,被广泛应用于医疗卫生、食品安全、工业漂白、环境消毒等领域,但长期使用H2O2会导致细菌对H2O2产生耐受性。【目的】通过文献计量学分析,了解细菌对H2O2应激反应领域的研究热点和前沿,并预测未来发展趋势。【方法】利用CiteSpace软件对过去10年细菌对H2O2应激反应的研究论文进行年发文量、国家、机构、被引期刊、作者、关键词等可视化分析。【结果】筛选到符合要求的SCI研究论文986篇。相关论文主要集中在微生物学、生物化学与分子生物学、生物技术与应用微生物学等领域。近10年该领域的研究主要聚焦在细菌内源性H2O2生成的影响因素、细菌氧化应激损伤、抗氧化防御系统、信号转导以及免疫调节等方面。【结论】目前关于细菌对过氧化氢应激反应的研究主要集中在细菌自身对H2O2的响应和调控,但是细菌与细菌之间、细菌与宿主之间的研究还很缺乏,推测未来研究方向主要在探究病原菌产生的内源性H2O2对宿主的影响和对宿主应激反应的适应机制,以及利用该机制开展抗菌杀菌治疗和环境污染修复应用。本文为细菌对H2O2应激反应的机制、病原菌的防控及其与宿主的相互作用研究奠定了重要基础。

    Abstract:

    [Background] Hydrogen peroxide (H2O2), an environmentally friendly disinfectant, is widely used in medical treatment, food safety, industrial bleaching, environmental disinfection and other fields. However, long-term use of H2O2 can lead to bacterial tolerance to H2O2. [Objective] Through bibliometric analysis, we can gain insights into the current research hotspots and frontiers within the realm of bacterial responses to H2O2 stress, thereby predicting the future development trends in this field. [Methods] CiteSpace was used to visually analyze the research papers about bacterial responses to H2O2 stress in the last ten years regarding the annual publications, countries, institutions, cited journals, authors, keywords, etc. [Results] A total of 986 SCI research papers that met the requirements were screened out, mainly involving the fields of Microbiology, Biochemistry and Molecular Biology, and Biotechnology and Applied Microbiology. The studies in this field in the last ten years mainly focused on factors affecting the endogenous H2O2 production, oxidative stress damage, antioxidant defense systems, signal transduction, and immune regulation. [Conclusion] The available studies in this field mainly focus on the response and regulation of bacterial themselves to H2O2. However, few studies report the interactions between different bacteria as well as between bacteria and hosts. The future research directions may include exploring the impact of endogenous H2O2 produced by pathogenic bacteria on the hosts and the bacterial adaption mechanism in dealing with host stress responses, which can be used for antibacterial and bactericidal treatment and environmental pollution remediation. This article lays a foundation for deciphering the mechanism of bacterial responses to H2O2 stress, preventing and controlling pathogenic bacteria, and revealing bacterial interactions with hosts.

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刘云飞,罗异,汪航,莫文涛,何明晖,程爽,梅慧婷,何进,苏键镁. 细菌对过氧化氢应激反应研究现状的可视化分析与发展趋势展望[J]. 微生物学通报, 2024, 51(6): 2227-2242

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  • 收稿日期:2023-11-22
  • 最后修改日期:
  • 录用日期:2023-12-28
  • 在线发布日期: 2024-06-07
  • 出版日期: 2024-06-20