布鲁氏菌外膜蛋白免疫原性研究进展

Research progress in immunogenicity of outer membrane proteins of Brucella

摘要:

布鲁氏菌病是由布鲁氏菌引起的世界范围内广泛流行的重要人畜共患传染病。外膜蛋白作为布鲁氏菌重要毒力因子，不仅在宿主感染过程中起着关键作用，还是布鲁氏菌潜在免疫原和保护性抗原，能刺激机体产生较强免疫应答，可作为布鲁氏菌的诊断抗原和新型疫苗靶点。本文对布鲁氏菌外膜蛋白免疫原性的研究进展进行了总结，以期为布鲁氏菌的实验室诊断和新型疫苗研发提供参考。

Abstract:

Brucellosis, caused by the bacteria of Brucella, is considered one of the major zoonotic diseases worldwide. As the key virulence factors of Brucella, outer membrane proteins not only play a vital role in the host immune process against Brucella but also are potential immunogens and protective antigens of Brucella. These proteins can stimulate strong immune response of the host and be used as diagnostic antigens and targets of novel vaccines against Brucella. We reviewed the research progress in the immunogenicity of key outer membrane proteins of Brucella, aiming to provide a reference for laboratory diagnosis and new vaccine development against Brucella.