Abstract:In view of the weak awareness of asepsis and limited knowledge application and higher-order thinking skills of the students, as well as the lack of ideological and political education in the course of Microbiology Experiment, we have reshaped the teaching objectives and identified the fundamental task of cultivating moral character and nurturing talents. We have innovatively proposed the STAR teaching concept, which integrates science (S), technology (T), art (A), and research (R) in comprehensive education and teaching. The STAR concept is seamlessly integrated into blended teaching, encompassing pre-class, in-class, post-class, and extended learning activities. Teaching practice has shown that the blended teaching model based on the STAR concept has enhanced students' intrinsic motivation, knowledge application, and innovation abilities. It stimulates higher-order thinking skills such as critical thinking, divergent thinking, and scientific research thinking, promoting students' comprehensive development, which helps students shine like stars (STAR). This study has strong universality and provides experience for the teaching reform of other courses.