Abstract:The global pandemic of COVID-19 has made people get aware of the great importance of Medical Microbiology and put forward new requirements for the education of basic medicine. This study focused on the teaching content and methods of Medical Microbiology in the cultivation of top-notch talents in basic medicine of the long-term system in the post-COVID-19 era. The teaching reform emphasized the concepts of being student-centered and keeping pace with the times and adopted the multi-track teaching mode to explore new approaches of teaching in Medical Microbiology. The teaching reform of this course reorganized the teaching content and strengthened the integration of microbiology with other medical knowledge. The cutting-edge research hotspots in microbiology were included in the teaching, highlighting the etiological knowledge of emerging infectious diseases and the importance of biosafety and epidemic prevention and control. The teaching system of experiments in Medical Microbiology was improved to cultivate students' innovation and practical abilities and stimulate students' interest and thinking in scientific research. The teaching reform of Medical Microbiology can provide a reference for the cultivation of top-notch talents in basic medicine of the long-term system in the post-COVID-19 era.