Abstract:Microbiology is one of the core courses for the undergraduates majoring in biological sciences (normal education). According to the concept of outcome-based education, we systematically designed this course considering the key issues in teaching by repositioning the teaching objectives, optimizing the teaching system, reforming the teaching mode, and building a multiple evaluation system. The "three-stage (before, during, and after class) five-mode (interactive participation, case-based improvement, question-oriented practice, ideological and political element integration, and continuous improvement)" teaching mode, the ideological and political education implementation path "building a community-expanding scenarios-innovating methods", and the continuous improvement mechanism based on a closed loop have been formed. These measures have effectively improved students' learning outcomes and provide reference for local normal universities in fostering teacher talents in biological sciences.