Abstract:The professional certification of teacher education follows the basic concept of student-centered and outcome-oriented teaching and continuous improvement. According to the concept of professional certification, we have carried out the teaching reform of Microbiology from four aspects:the positioning of course objectives, the optimization of teaching content, the adjustment of teaching organization form, and the improvement of assessment mode. The practice results show that the reform helps to fully mobilize students' learning enthusiasm and initiative, strengthen students' normal skills, and improve students' comprehensive ability, which achieves good teaching results.