Abstract:The course of Advanced Microbiology Experiments aims to cultivate the scientific research thinking, innovative consciousness, exploring spirit, and practical abilities of newly enrolled graduates. To improve the quality of teaching and address the key issues in teaching, our team adheres to the educational philosophy of being student-centered and outcome-based, and optimizes the teaching content by designing basic, research-oriented, and exploratory innovative experimental projects. Diversified teaching activities such as group teaching, interactive teaching, blended teaching, and flipped classroom were implemented with reliance on the smart classroom and online teaching platform. The practical teaching was carried out with intelligent open laboratories and scientific research resources. A comprehensive assessment was adopted throughout the entire process to evaluate the comprehensive scientific research literacy of graduates. Finally, a teaching system suitable for fostering graduates majoring in microbiology at Guizhou University was built. The practice has shown that the teaching mode of "classroom+online+practice" has achieved good results, which can stimulate graduates' interest and enthusiasm in scientific research, cultivate their practical and innovation abilities, and improve their comprehensive scientific research literacy.