Abstract:Online and offline blended teaching has become a new form of teaching in higher education. The "Experimental Space" platform supports shared applications of virtual simulation projects, which is a supporting condition for teachers to carry out blended teaching. Fermentation Engineering Experiments is a comprehensive and practical course in bioengineering. In response to the pain points in the teaching of this course, we combined the high-quality virtual simulation resources shared on the platform with the self-designed online learning resources to create the production scenarios for offline experimental classes. The offline experimental classes simulated production reality and assigned "job" roles to carry out experimental tasks. After class, the task was to create experimental reports and videos to achieve a closed learning loop. The combination of online and offline teaching has improved students' initiative and enthusiasm in learning, enhanced their operational skills and problem-solving ability, and formed a blended teaching mode suitable for experimental teaching. It provides an example for the teaching application of shared virtual simulation projects.