Abstract:In the implementation of the Double First-Class initiative, international exchange and cooperation is an important part. Teaching specialized courses in English can enhance students' ability to master, understand, and use knowledge, while also improving their proficiency in using, expressing, and writing in English. It is worth exploring how to achieve the goals of teaching advanced, innovative, challenging content of specialized courses in English, enhance students' interest and classroom participation, and improve their professional and English communication abilities. The optional course Microbial Genetics has been taught in English in Nankai University for more than 10 years. The teaching emphasizes the student-centered concept and ability training, and continuous exploration and reform have been carried out in teaching content, classroom teaching, language ability, and assessment methods. In terms of teaching content, we combined knowledge learning with scientific logic and experimental technology according to students' knowledge background and needs. According to students' English skills, we integrated teaching, questioning, and discussion to enhance students' focus and English communication abilities in the process of classroom teaching. In the design of exercises, challenging questions were used to make students learn and apply knowledge actively. In terms of the assessment, open-book examination was adopted to train students' ability to use knowledge and English-language articles to solve problems, so as to improve their scientific research abilities. After continuous exploration and practice, our teaching practice has stimulated students' enthusiasm for learning and participation in class and enabled students to improve their scientific research ability and English skills on the basis of fully understanding and mastering the class content, achieving good teaching performance.