Abstract:The curriculum teaching of Microbiology Experiment of pharmaceutical engineering is designed according to the concept of outcome-based education (OBE) required by the professional certification of engineering education, with the aim of fostering students’ abilities of independent learning and practical innovation. The teaching projects of this course were set at three levels: introductory, advanced, and independent projects. The teaching process was student-centered, with the support of online teaching methods and competition mechanisms. The practical results showed that project-based teaching reform significantly improved both the teaching performance and the learning effectiveness. Students achieved significant progress in experiment operation and paper writing. Therefore, this teaching method is worth summarizing and promoting in the future.