生物被膜态益生菌控制病原菌感染及其开发策略

Measures for developing probiotics biofilm for pathogen infection control

摘要:

生物被膜是细菌的一种特殊生存方式。生物被膜感染在临床中的高耐药性问题、反复性问题、迁延性问题等是临床中亟待解决的问题。益生菌作为机体共生微生物的一部分，能够通过多种方式对抗病原菌。本文就临床生物被膜治疗中亟待解决的问题做出了部分总结，归纳总结了部分益生菌生物被膜对抗病原菌生物被膜的作用机制，而且还从改进益生菌生物被膜研究方法、增强益生菌生物被膜稳定性和开发新型生物被膜态益生菌的角度出发，就如何开发生物被膜态益生菌的策略方法进行了综述。

Abstract:

Biofilm is a special way for bacteria to survive. Antibiotic resistance, recurrence, and transfer of biofilm infection are urgent problems to be solved in clinical practice. Probiotics, as part of the microorganisms in the host, can restrain pathogens via a variety of ways. This paper summarizes the mechanisms of probiotics biofilm against pathogenic bacterial biofilm, and further reviews the measures for improving the research method and enhancing the stability of probiotics biofilms and developing new probiotics biofilms.