Abstract:With the development of virtual simulation experiment teaching in China, group learning has attracted increasing attention and been applied to practical teaching. However, there are few studies about the teaching practices combining group learning with virtual simulation experiment courses. In view of the typical problems existing in the practical teaching of microbial experiments, we took the Microbial Physiology course for postgraduates at Harbin Institute of Technology as an example to illustrate the virtual simulation experiment teaching based on collaborative and interactive learning, aiming to create a first-class experiment/practice course of microbiology. This paper describes the connotation, elements, and advantages of collaborative and interactive learning, discusses the application of this learning mode in virtual simulation experiment teaching of Microbial Physiology, and summarizes the deficiency and development direction of this teaching method.