放线菌代谢产物的研究进展：基于Web of Science (WOS)和中国知网(CNKI)

Advances in metabolites of actinobacteria: a study based on Web of Science(WOS) and China National Knowledge Infrastructure(CNKI)

摘要:

【背景】放线菌是一类极其重要的微生物，代谢产物丰富，在医药、生物技术、农业和酶工业等领域均有广泛应用。【目的】客观分析放线菌代谢产物的研究进展，为该领域相关工作人员提供有效情报，推动该领域高质量发展。【方法】对Web of Science (WOS)和中国知网(China National Knowledge Infrastructure, CNKI)数据库中放线菌代谢产物的发文数量、发文国家、发文机构、发文期刊、发文出版社、发文作者、被引文章和研究方向进行统计分析，利用H指数对相关影响力进行综合评价，其研究热点、发展趋势通过CiteSpace和VOSviewer软件进行可视化分析。【结果】WOS结果显示，放线菌代谢产物研究领域全球影响力最大的国家是美国，影响力最大的机构是美国加利福利亚大学，影响力最大的期刊是美国Applied and Environmental Microbiology，影响力最大的出版社是Elsevier，影响力最大的作者是来自英国约翰英纳斯研究中心微生物学部的Mervyn J Bibb教授。全球放线菌代谢产物领域的主要研究方向是微生物学，研究热点是生物合成。研究趋势由2000年前对基因和抗生素相关的研究，转变为2000年后对肠道微生物群和天然产物发现相关的研究。CNKI结果显示，放线菌代谢产物研究领域中国影响力最大的机构是西北农林科技大学，影响力最大的期刊是微生物学通报，影响力最大的作者是云南大学徐丽华教授。放线菌代谢产物领域的主要研究方向是生物学，研究热点是放线菌。研究趋势由2000年前对抗生素和生物合成相关的研究，转变为2000年后对多样性和鉴定相关的研究。【结论】目前全球放线菌代谢产物研究在快速发展，美国在该领域处于全球领先地位，其发文数量、H指数均排名世界首位，发文机构、发文期刊、发文出版社在世界范围内具有较大影响力。中国发文数量全球排名第二，H指数全球排名第五，相关发文机构、学者在国内外具有一定影响力。未来中国在放线菌代谢产物研究领域应加强高质量文章发表和期刊建设、出版社建设，加强肠道微生物群和天然产物发现相关的研究，以带动在该领域研究实力的整体提升。

Abstract:

[Background] Actinobacteria are a class of microorganisms capable of producing rich metabolites, which are widely used in medicine, biotechnology, agriculture, and enzyme industry. [Objective] To review the research progress in the metabolites of actinobacteria and provide effective information for the high-quality development of this field. [Methods] Statistical analyses were conducted on the number, countries, institutions, journals, publishers, and authors of publications, cited articles, and research directions of the metabolites of actinobacteria. The relevant articles were retrieved from the Web of Science (WOS) and China National Knowledge Infrastructure (CNKI). The H-index was calculated to comprehensively evaluate the impact. The research hotspots and development trends were visualized in CiteSpace and VOSviewer. [Results] The analysis based on WOS showed that the United States, the University of California, Applied and Environmental Microbiology, and Elsevier were the country, institution, journal, and publisher, respectively, with the highest impact in this field. Professor Mervyn J Bibb in the microbiology department of the John Innes Centre in the UK was the author with highest impact. The main research direction in the metabolites of actinobacteria worldwide was Microbiology, and the research focused on the biosynthesis. The research trend evolved from the genes and antibiotics before 2000 to gut microbiota and natural products after 2000. The analysis based on CNKI showed that Northwest A&F University, Microbiology China, and Professor Lihua Xu at Yunnan University were the institution, journal, and author, respectively, with the highest impact in this field in China. The main research direction was Biology, and the research focused on actinomycetes. The research trend in this field in China shifted from antibiotics and biosynthesis before 2000 to diversity and identification after 2000. [Conclusion] The research on the metabolites of actinobacteria is flourishing worldwide. The United States was a global leader in this field, ranking first in the world in terms of the number of publications and the H-index, with strongly influential institutions, journals, and publishers. China ranked second in terms of the number of publications and fifth in terms of the H-index, and the publishing institutions and scholars had influences at home and abroad. In the future, China should strengthen the publishing of high-quality articles and the building of journals and publishers in the research on the metabolites of actinobacteria and double the efforts to study gut microbiota and discover natural products, so as to build up the strength in this research field.