肠道微生物群在糖尿病肾病防治中的研究进展

Intestinal microbiome in the prevention and treatment of diabetic kidney disease

摘要:

糖尿病肾病(diabetic kidney disease, DKD)是由糖尿病引起的严重的代谢性疾病，在高糖情况下，引起肾脏慢性炎症和氧化应激，破坏肾脏生理结构并导致肾脏间质纤维化。大量研究表明，肠道微生物群能够影响机体代谢和健康。本文通过梳理肠道微生物群与DKD相关性的最新研究成果，以期阐明肠道微生物群在DKD的发生和防治过程中的作用。首先，阐明了肠道屏障和肠道微生物群代谢物与DKD的联系；其次，总结近几年抗DKD研究中的作用机制；最后，对补充益生元、益生菌和粪便移植在DKD治疗中的可行性进行了讨论。通过梳理相关内容，本文可为DKD的防治提供一定的理论参考与数据支持。

Abstract:

Diabetic kidney disease (DKD) is a serious metabolic disease caused by diabetes mellitus. In high glucose, DKD causes chronic inflammation and oxidative stress in the kidney, destroys the physiological structure of the kidney, and leads to renal interstitial fibrosis. Numerous studies have shown that intestinal microbiome influences the body’s metabolism and health. This review summarized the latest research findings on the relevance of the intestinal microbiota to DKD, which aimed to elucidate the effects of the intestinal microbiota on the prevention and treatment of DKD. In addition, the association between intestinal barrier and intestinal microbiome metabolism with DKD was established, and the related mechanisms of the intestinal microbiome against DKD in recent studies were summarized. What’s more, the feasibility of supplementing prebiotics and probiotics as well as fecal transplantation in the treatment of DKD was discussed. By combing relevant content, this review provides certain theoretical references and data support for the treatment of DKD.