Enteroviruses belonging to the family Picornaviridae include poliovirus and other major human pathogens and have become one of the major threats to global health. Innate immunity is an important host defense against viral infection. Diverse enteroviruses have evolved multiple ways to evade immune recognition or inactive the innate immune system. We reviewed the recent studies about the mechanisms of enteroviruses regulating innate immune response and systematically introduced the molecular characteristics of enterovirus evasion of interferon-dependent and interferon-independent antiviral innate immune defense, hoping to provide a reference for deciphering enterovirus pathogenesis and developing targeted antiviral drugs.
