非编码小RNA对细菌毒力及耐药性的调控作用研究进展

sRNA’s regulation of bacterial virulence and antibiotic resistance

摘要:

近年来的研究发现，细菌非编码小RNA (small non-coding RNA, sRNA)对其不同生理进程起到了重要的调控作用。随着大量sRNA被发现并鉴定，细菌sRNA的功能被逐步阐明，其可在转录后水平广泛调控细菌的生理代谢、毒力及耐药性等。本文综述了sRNA对细菌毒力和耐药性调控作用的研究进展，对揭示细菌转录后水平毒力及耐药性调控机制具有一定意义。

Abstract:

It has been revealed that bacterial small non-coding RNAs are post-transcriptional regulatory molecules that tune important processes in bacterial physiology, such as the metabolism, virulence, and antibiotic resistance. In this paper, we review sRNAs' regulation of bacterial virulence and antibiotic resistance, which is of significance for revealing the post-transcriptional mechanism of bacterial virulence and drug resistance.