The accelerated industrialization has aggravated the water pollution in China. The discharge of high-salinity organic wastewater will lead to further deterioration of the environment. The effective treatment of wastewater is essential for the recycle of water resources. This paper reviews the research progress in microbial treatment of high-salinity organic wastewater through typical cases and introduces the survival and tolerance mechanisms of microorganisms in high-salinity environment and the research and application of microbial treatment of high-salinity industrial organic wastewater. Furthermore, this paper puts forward the existing problems and the prospect of the research and application in this field, which can provide references for the development of biological treatment of high-salinity industrial organic wastewater.