植物毒素thaxtomins生物合成及其分子调控研究进展

Biosynthesis and molecular regulation of phytotoxin thaxtomins: a review

摘要:

马铃薯疮痂病(potato scab)是世界范围内广泛存在的土传细菌性病害，难以防治。植物毒素thaxtomins由疮痂病链霉菌(Streptomyces scabies)次级代谢产生，是马铃薯疮痂病的主要致病原因，对马铃薯等作物产业造成严重危害。鉴于疮痂病链霉菌在农业上的重要作用，其中thaxtomins生物合成过程和分子调控得到越来越多的关注，并取得了较好的进展。本文综述了thaxtomins的结构特征、生物合成与异源表达，并重点介绍了疮痂病链霉菌中thaxtomins生物合成的分子调控机制等方面的研究进展，有利于深入认知疮痂病链霉菌次级代谢调控网络，为未来开发新型马铃薯疮痂病的防治策略提供理论指导。

Abstract:

Potato scab, a soil-borne bacterial disease that exists worldwide, is difficult to control. The phytotoxin thaxtomins, produced by the secondary metabolism of Streptomyces scabies, are the main cause of potato scab, and result in serious damage to potato and other crop industries. Due to the serious impact of S. scabies on agriculture, the biosynthesis and molecular regulation of thaxtomins have attracted many attentions and made great progress. This article reviewed the structural characteristics, biosynthesis, and heterologous expression of thaxtomins, focusing on the molecular regulatory mechanism of thaxtomins biosynthesis in S. scabies. This review helps deeply understand the regulatory network of the secondary metabolism of S. scabies, and provides theoretical guidance for the development of new control strategies for potato scab in the future.