肠道菌群在脊髓损伤后胃肠道炎症反应中的研究进展

Gut microbiota in gastrointestinal inflammatory response after spinal cord injury: a review

摘要:

脊髓损伤(spinal cord injury, SCI)目前尚无有效的治疗手段。脊髓损伤后，患者常伴有严重的胃肠功能障碍，严重影响患者的生活质量。研究发现，脊髓损伤后肠道菌群的紊乱和脊髓损伤后的胃肠道功能障碍密切相关。因此，本文围绕脊髓损伤后肠道菌群的变化，探讨肠道菌群在迷走神经、下丘脑-垂体-肾上腺和肠道菌群代谢物3个途径中发挥的作用，及与胃肠道炎症反应相关的研究进展。

Abstract:

There is no way to reverse spinal cord injury. In the case of spinal cord injury, patients always suffer from gastrointestinal dysfunction which impacts the quality of life. It has been reported that gut microbiota disorder after spinal cord injury is connected to the gastrointestinal dysfunction. Thus, this paper mainly explored the role of gut microbiota in vagus nerve system, hypothalamic-pituitary-adrenal axis and gut microbiota metabolites three pathways, and the relationship with gut inflammatory through gut microbiota changes after spinal cord injury.