The rhizosphere microbiome is one of the key determinants of crop health and an important factor regulating crop interactions with biotic and abiotic environments. Plant growth-promoting rhizobacteria (PGPR) interact with crops and soil in complex ways through chemical communication to promote crop growth. This paper reviewed the growth-promoting mechanism of PGPR on crops, the interaction between PGPR and crops and its application in agricultural practice, and the development trend of the application of PGPR in agricultural practice was also prospected, aiming to provide new ideas and theoretical support for the application and research of PGPR in future.