猪丁型冠状病毒感染引致细胞自噬的研究进展

Autophagy induced by porcine deltacoronavirus infection: a review

摘要:

细胞自噬是利用溶酶体对细胞内多余、受损、死亡的蛋白质和细胞器进行降解的一种过程。细胞受到病毒等刺激时，为了维持内环境稳态，细胞自噬常有发生，虽然细胞自噬可以有效抵抗病毒入侵，但这个过程也会对病毒感染产生负作用。猪丁型冠状病毒(porcine deltacoronavirus，PDCoV)感染细胞时会引发细胞发生自噬现象。本文从自噬的种类和发生流程、自噬与PDCoV互作及相关检测方法等方面，对细胞自噬在PDCoV感染中如何抵抗和促进病毒复制进行了阐述，对进一步研究PDCoV致病机制和防控具有积极意义。

Abstract:

Autophagy is a cellular process that removes unnecessary or dysfunctional components through a lysosome-dependent regulated mechanism. It occurs in the presence of stimuli such as virus to maintain homeostasis. Autophagy can help defend against viral invasion and may promote viral replication. Porcine deltacoronavirus (PDCoV) can induce autophagy. In this paper, we summarize the types and process of autophagy, interaction of autophagy with PDCoV, and related detection methods, to elucidate how autophagy resists the infection and supports the replication of PDCoV. The findings are expected to serve as a reference for further research on the pathogenic mechanism of PDCoV and prevention and control of this virus.