cGAS-STING信号通路在畜禽疾病中的研究进展

Role of cGAS-STING signaling pathway in livestock and poultry diseases: a review

摘要:

cGAS-STING信号通路是一种细胞内DNA感受器，可以识别自身病变或外部进入细胞质中的双链DNA。其不仅与肿瘤、病毒和细菌感染及自身免疫系统疾病密切相关，而且在非特异性免疫系统中发挥重要作用。截至目前，国内外对于cGAS-STING信号通路的研究主要集中在哺乳动物肿瘤相关性疾病及与先天性免疫系统相关的疾病中，而通路对畜禽疾病调控的影响机制非常重要。本文以cGAS-STING信号通路在宿主受到病原感染中发挥的作用为切入点，对其在不同畜禽病原感染中的调控作用进行综合论述，以期为畜禽疾病的防控提供理论依据和参考。

关键词:cGAS-STING信号通路;畜禽疾病;天然免疫;调控作用

Abstract:

The cGAS-STING signaling pathway is an intracellular DNA sensor that recognizes self-lesioned or externally entered double-stranded DNA in the cytoplasm. It not only is associated with tumors, viral and bacterial infections, and autoimmune diseases but also plays a role in the nonspecific immune system. The available studies of cGAS-STING signaling pathway mainly focus on mammalian tumor-related diseases and the diseases related to the innate immune system. Considering the significant regulatory role of CGAS-STING signaling pathway, we comprehensively expound the role of this pathway in pathogen infection of livestock and poultry, with an view to provide a theoretical basis for the prevention and control of livestock and poultry diseases.

Key words:cGAS-STING signaling pathway;livestock and poultry diseases;innate immunity;regulation