植入物动物感染模型在葡萄球菌生物膜研究中的应用与进展

Application of foreign body infection models in the biofilm of Staphylococcus spp.: a review

摘要:

葡萄球菌生物膜引起的持续性感染及耐药性问题一直是临床治疗的难题，围绕生物膜形成分子机制的研究成为防治葡萄球菌生物膜相关感染的关键。建立葡萄球菌感染动物模型有利于研究体内生物膜形成、扩散、致病机制及药物的体内抗生物膜效果评估等。然而，动物体内生物膜形成的影响因素多，如动物种类、植入材料、接种部位、感染剂量、观察时间及评估方法等均会影响体内生物膜形成。结合本课题研究，系统地总结了近40年来葡萄球菌生物膜感染动物模型，重点综述动物模型的建立方法、适用范围及优缺点，为葡萄球菌生物膜感染的防治提供理论依据。

Abstract:

Persistent infection and drug resistance caused by the biofilm of Staphylococcus spp. have always been a difficult problem in clinical treatment. The research on the molecular mechanism of biofilm formation has become the key to the prevention and treatment of infections associated with the biofilm of Staphylococcus spp.. The establishment of animal models of infection by Staphylococcus spp. is conducive to the study of biofilm formation, diffusion, and pathogenesis and the in vivo evaluation of the anti-biofilm effect of drugs. However, there are many influencing factors of biofilm formation in animals, such as animal species, implantation material, inoculation site, infection dose, observation time, and evaluation method. This study systematically summarized the animal models of biofilm infection by Staphylococcus spp. in the past 40 years, focusing on the establishment methods, application scope, advantages, and disadvantages of animal models, thereby providing a theoretical basis for the prevention and treatment of biofilm infection by Staphylococcus spp..