Abstract:Influenced by the epidemic of Covid-19 pneumonia, online and offline blended teaching has gradually become a new normal teaching mode. How to improve the teaching effect, ensure the substantive equivalence between online teaching and offline teaching, and realize effective teaching is the key. Adhering to the teaching philosophy of student-centered, result-oriented and continuous improvement, and aiming at the problems existing in the current Microbiology teaching, the course team used the effective teaching mode of O-AMAS to reconstruct the teaching process of Microbiology course based on the analysis and grasp of students’ learning characteristics and cognitive style, construction of online teaching resources and optimization of teaching content. Our team adopted a diversified teaching mode, implemented effective evaluation and feedback, promoted deep learning through simple summary, and fully mobilized students’ enthusiasm for autonomous learning, thus enhancing the teaching effect of the course.