肠道与泌尿系统的微生物对肾结石发病机制影响的研究进展

Effect of microorganisms in intestinal tract and urinary system on the pathogenesis of renal calculus:a review

摘要:

肾结石是成人泌尿系统的常见疾病。它会影响肾脏的生理机能，还会导致尿路感染从而对人体健康造成一定危害。肾结石周围存在一个多元化的微生物群落，而肠道微生物和泌尿系统微生物的变化可能引起肾结石的发生与发展。其中双歧杆菌(Bifidobacterium)、乳酸杆菌(Lactobacillus)和肠杆菌科(Enterobacteriaceae)与肾结石发生较为密切。本篇综述着重介绍了肠道微生物与泌尿系统微生物在肾结石形成过程中的关联性，同时也对肾-肠轴概念，肠道微生物从短链脂肪酸产生、草酸盐变化和炎症发生对肾结石的影响，以及肾结石的预防与治疗等方面做出了介绍。

Abstract:

Renal calculus, a common urinary disorder in adults, influences the physiological function of the kidney and leads to urinary tract infection, thus threatening human health. Renal calculi are surrounded by a diversified microbial community, and the changes of microorganisms in the intestinal tract and urinary system may cause the occurrence and development of renal calculus. Particularly, Bifidobacterium, Lactobacillus, and Enterobacteriaceae are closely related to the occurrence of this disease. This review focused on the role of microorganisms in intestinal tract and urinary system in the formation of renal calculi. In addition, we also introduced the kidney-gut axis, influence of intestinal microorganisms on renal calculus from the production of short-chain fatty acids, the change of oxalate, and the occurrence of inflammation, and the prevention and treatment of this renal disease.