持留菌的控制研究进展

Control of persisters:a review

摘要:

持留菌是高度耐受抗生素的细菌亚群。持留菌的出现加剧了抗生素治疗感染性疾病的难度，对人类的生命健康造成不可忽视的威胁。因此，如何控制与去除持留菌成为目前的一个研究热点。本文主要综述了持留菌的基本特性与危害，分析了持留菌形成的机制，并系统地总结了目前持留菌控制与去除的方法。本文对研究控制持留菌及改善持续性感染的治疗具有一定的指导意义和参考价值。

Abstract:

Persisters, a subgroup of bacteria that can survive high dosage of antibiotics, make it more difficult to treat infections with antibiotics and threaten human life and health. How to control and remove persisters has become a research hotspot at the moment. In this paper, we summarize the characteristics and harms of persisters, analyze the formation mechanism of them, and sum up methods for controlling and removing this subgroup. This review is expected to guide the control of persisters and the treatment of persistent infection.