嗜肺军团菌II型分泌系统及其底物的研究进展

Research progress in the type Ⅱ secretion system of Legionella pneumophila and its substrates

摘要:

嗜肺军团菌(Legionella pneumophila，L. pneumophila)是研究病原菌-宿主相互作用的重要模式菌株之一，其独特的分泌系统及底物效应蛋白的结构与功能是病原微生物领域的研究热点。II型分泌系统(type II secretion system，T2SS)对促进细菌在环境和人类宿主中的生存至关重要。嗜肺军团菌Legionella secretion pathway (Lsp)系统是革兰氏阴性病原菌中一个典型的T2SS。本文综述了L. pneumophila的T2SS及其底物效应蛋白的研究进展，重点介绍其结构与功能，为深入了解革兰氏阴性病原菌的T2SS功能和作用机制提供参考。

Abstract:

Legionella pneumophila (L. pneumophila) is a distinct model for pathogen-host interaction research. Its unique secretion systems as well as the structures and functions of their substrate effectors are the research hotspots in the field of pathogenic microorganism. Type Ⅱ secretion system (T2SS) plays a major role in promoting bacterial survival in the environment and in human hosts, and Legionella secretion pathway (Lsp) is a typical T2SS in Gram-negative pathogens. This review briefly summarizes the research progress of L. pneumophila T2SS and its substrate effectors, emphasizing on their structures and functions, so as to provide in-depth understanding of the function and mechanism of T2SS in Gram-negative pathogens.