硫酸盐还原菌与肠道疾病相关性的研究进展

The association between sulfate-reducing bacteria and gut-related diseases: a review

摘要:

硫酸盐还原菌(sulfate-reducing bacteria，SRB)是肠道菌群的重要组成成员之一。SRB在其增殖与新陈代谢过程中会产生硫化氢。现有研究显示，SRB的过度繁殖与炎症性肠病(inflammatory bowel disease，IBD)、肠易激综合征(irritable bowel syndrome，IBS)、乳糜泻(celiac disease，CLD)和结直肠癌(colorectal cancer，CRC)等密切相关，但目前尚无相关文献对SRB在肠道疾病中扮演的角色、致病机理和肠道微生态等研究进行系统性的综述。SRB在肠道疾病中的分布特征及其致病机制值得进一步总结与探讨。本文收集过去10年来发表的关于SRB与肠道疾病的文献并进行详细分析与归纳，对SRB在宿主肠道内的分布与生理特征、SRB在不同肠道疾病的相关分布特点，以及SRB致病机制的研究进展等方面进行详细论述，以期增加本领域研究人员对SRB的重视。同时，本文对未来如何深化SRB在肠道相关疾病的研究方向进行探讨，以期为SRB相关肠道疾病的预防与治疗提供一定参考。

关键词:肠道菌群;硫酸盐还原菌;肠道疾病;硫化氢

Abstract:

Sulfate-reducing bacteria (SRB), key members of the gut microbiota, produce hydrogen sulfate (H₂S) during growth and metabolism. Studies have demonstrated that the overgrowth of SRB is associated with inflammatory bowel disease (IBD), irritable bowel syndrome (IBS), celiac disease (CLD), and colorectal cancer (CRC). However, there is no relevant research review to systematically address the role of SRB in intestinal diseases, pathogenesis, and intestinal microenvironment. Therefore, the characteristics of SRB in intestinal diseases and its pathogenic mechanism deserve to be further summarized and explored. This review collected the literature on SRB-related intestinal diseases published in the past decade and conducted a detailed analysis and summary. The research progress and other aspects were discussed in detail to increase the attention of researchers in this field to SRB. Moreover, we pointed out several areas that need in-depth research for understanding the role of SRB in intestinal diseases. We hope that this review will serve as a valuable reference for the treatment and prevention of SRB-associated diseases in the foreseen future.

Key words:gut microbiota;sulfate-reducing bacteria;intestinal diseases;hydrogen sulfate