下一代益生菌Akk菌的研究进展

Research progress of the next-generation probiotics Akkermansia muciniphila

摘要:

Akk菌(Akkermansia muciniphila)是具有巨大发展潜力的下一代益生菌，被广泛认为是改善炎症性肠病、肠易激综合征、糖尿病、肥胖症和渐冻症等疾病的一种新的潜在候选菌。近年来，随着人们对肠道共生菌重视程度的加深和各种组学技术的发展，Akk菌迅速成为益生菌研究领域的热点。然而，目前国内外有关Akk菌最新研究进展的归纳总结仍较少。因此，本文对近十年国内外有关Akk菌取得的最新研究进展进行综述，从Akk菌对宿主健康的调控作用，Akk菌的分离、鉴定和培养，以及Akk菌研究面临的挑战、机遇和前景等几方面进行阐述，以期为国内外同行对Akk菌的进一步深入研究和开发提供参考。

Abstract:

Akkermansia muciniphila, the next generation of probiotics with significant development potential, is widely considered to be a new candidate for alleviating diseases such as inflammatory bowel disease, irritable bowel syndrome, diabetes, obesity, and amyotrophic lateral sclerosis. With the increasing attention to intestinal bacteria and the advancement of omics technologies in recent years, A.muciniphila has rapidly become a hot spot in the research on probiotics. However, at present, the latest research progress of A.muciniphila remains to be summarized. Therefore, this paper summarizes the research achievements of A.muciniphila in the recent decade from the perspectives of the regulatory effect of A.muciniphila on host health, the isolation, identification, and culture of A.muciniphila, the challenges, opportunities, and prospects of research on A.muciniphila, aiming to provide reference for the further research and development of A.muciniphila.