Abstract:Viral disease threaten human beings, animal and plant health seriously. At present, the measures and effects for preventing and treating viral disease are limited. It is necessary to develop non-toxic and eco-friendly antiviral agents to prevent and control viral disease. Probiotics Bacillus species play an antiviral role by producing metabolites or components such as ribonuclease and extracellular polymers, and enhancing immunity, which is expected to be further developed for the prevention and treatment of viral disease.