鞭毛介导的空肠弯曲菌氧应激机制研究进展

Research progress on the mechanism of flagellum-mediated oxidative stress response of Campylobacter jejuni

摘要:

空肠弯曲菌(Campylobacter jejuni)是世界范围流行的食源性人兽共患病原菌，是革兰氏阴性微需氧菌。其对氧气、温度、pH和胆汁酸盐等环境条件极其敏感，在环境传播和宿主定殖过程中会遭受许多不利条件，包括致命的活性氧自由基(reactive oxygen species，ROS)，因此，抵抗活性氧自由基是空肠弯曲菌进化的一种重要策略。空肠弯曲菌为抵抗氧应激进化出了多种响应机制，其中，鞭毛及其介导的运动力也参与氧应激。本文对国内外有关空肠弯曲菌氧应激研究进展及鞭毛介导的氧应激机制进行综合阐述，以期为进一步完善空肠弯曲菌氧应激调控系统奠定基础，并为弯曲菌源头防控提供思路。

Abstract:

Campylobacter jejuni, a worldwide prevalent food-borne zoonotic pathogen, is a Gram-negative microaerophilic bacterium. It is extremely sensitive to environmental conditions such as oxygen, temperature, pH, and bile salts, and suffers from adverse conditions including lethal reactive oxygen species (ROS) during the spread and colonization. Therefore, the response to ROS is an important strategy for C. jejuni. C. jejuni has evolved a variety of mechanisms to resist oxidative stress, which involve flagella and flagellum-mediated motility. Therefore, we comprehensively expounded the research progress on the mechanisms of C. jejuni in response to oxidative stress, especially that mediated by flagella, aiming to lay a foundation for further improving the regulation system of Campylobacter jejuni in response to oxidative stress and provide information for the prevention and control of Campylobacter at the source.